O r i e n s C e l l s


I Would Like to Know About

  • How do Cell Therapies Work?

    Cell therapy (also called cellular therapy or cytotherapy) is therapy in which cellular material is injected into a patient; this generally means intact, living cells. Cell therapy is targeted at many clinical indications in multiple organs and by several modes of cell delivery. Accordingly, the specific mechanisms of action involved in the therapies are wide ranging. Some of the cells used in cell therapy include stem , T, dendritic, natural killer, genetically modified, plasma, and red blood cells.

  • What are Mesenchymal Stem Cells (MSC)?

    Mesenchymal stem cells (MSCs) are multipotent adult stem cells, which can self-renew by dividing and can differentiate into various tissues including, bone, cartilage, adipose tissue (fat cells), connective tissue and muscle.

  • Where do mesenchymal stem cells come from?

    They are majorly isolated from bone marrow. However, cells which display characteristics of mesenchymal stem cells are also found in adipose tissue, peripheral blood, cord blood, skin, cartilage, synovial fluid, bone, tendons, muscle, salivary gland, dental tissues, fetal membrane, endometrium, Wharton’s jelly and sub-amniotic umbilical cord lining membrane.

  • Why do mesenchymal stem cells show immunosuppression and low immunogenicity?

    Mesenchymal stem cells avoid immune response by expressing low levels of class I MHC molecules and not expressing class II MHC and co-stimulatory molecules (CD80, CD86 and CD40).It also inhibits immunogenic activity of T cells, B cell, dendritic cells and natural killer cells either through cell-cell contacts or soluble factors.

  • Are there any clinical treatments available using MSC?

    No, still they are in clinical trials. The multi-lineage potential and homing ability of MSC offers therapeutic strategies to treat skeletal and neurodegenerative diseases. Considering the secretion of anti-inflammatory molecules and immunoregulatory effects, MSCs are also promising to treat autoimmune and inflammatory diseases.

  • What is NK (Natural Killer) Cell Therapy?

    When NK cells respond to the antibodies bound to cancer antigens on the surface of cancer cells, NK cells are activated and attacks cancer cells. The cancer cells that survive make themselves invisible to the T cells instructed to attack them (CTLs: cytotoxic T lymphocytes) by changing themselves over time in order to avoid their attack. NK cells are considered to attack such cancer cells rather effectively. On the other hand, NK cells are known to be less likely to attack cancer cells with MHC class I molecules, but this weak point can be overcome by enhancing the cancer-killing molecules in NK cells.

  • How Does NK Therapy Work?

    In NK cell therapy, lymphocytes (including NK cells) are collected from patients’ blood. NK cells play a role in attacking abnormal cells such as cancer cells. Once harvested, the NK cells are cultured and grown in large amounts in order to further enhance their ability to kill cancer cells. The NK cells are then returned to patients’ bodies in order to strengthen their immunity.

  • Are Antioxidants Good for Delaying Aging?

    One of the biggest skin concerns associated with oxidation is accelerated aging. But, do antioxidants actually delay these effects? “Yes. Antioxidant serums help neutralize free radicals induced by UVA/UVB, infrared radiation, and ozone pollution, which all visibly accelerate skin aging.”